Task Order #1
The inaugural project for the LITES network (Task Order #1) will be to conduct an observational study with the primary aim to understand the epidemiology of traumatic injuries in the US; including regional variations in severity and types of injury, modes and methods of management, and survival and recovery rates (outcomes). This initial foundational study will also yield important guidance and create opportunities to improve efficiency for subsequent clinical research to be conducted using the LITES capability, including but not limited to directing certain lines of research to the most appropriate centers and systems within the network.
Task Order #2
The second project of the LITES Network (Task Order #2) is a four-year observational study examining the use of whole blood resuscitation compared to component resuscitation in poly-trauma patients with hemorrhagic shock. The study will further characterize outcome benefits in those with traumatic brain injury and blood pressure and resuscitation endpoints in poly-trauma patients with traumatic brain injury.
Task Order #5
The Prehospital Airways Control Trial (PACT) is a 5-year, pragmatic, unblinded randomized trial comparing the standard airway management strategy with a strategy of initial use of supraglottic airway (SGA) for the airway management of prehospital trauma patients. PACT uses a stepped wedge cluster design, meaning the sites transition on a schedule from standard airway management to first pass management with SGA. PACT is also an Exception from Informed Consent (EFIC) study; more information on that aspect can be found here.